Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth(SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

Sugiaman, Vinna Kurniawati and Djuanda, Rudy and Pranata, Natallia and Naliani, Silvia and Delmolsky, Wayan L. and Jeffrey, Jeffrey (2022) Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth(SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp. Polymers, 14. ISSN 2073-4360

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Abstract

Maintaining dental pulp vitality and preventing tooth loss are two challenges in endodontic treatment.A tooth lacking a viable pulp loses its defense mechanism and regenerative ability, making it more vulnerable to severe damage and eventually necessitating extraction. The tissue engineering approach has drawn attention as an alternative therapy as it can regenerate dentin-pulp complex structures and functions. Stem cells or progenitor cells, extra cellular matrix, and signaling molecules are triad components of this approach. Stem cells from human exfoliated deciduous teeth (SHED) are a promising, noninvasive source of stem cells for tissue regeneration. Not only can SHEDs regenerate dentin-pulp tissues(comprised of fibroblasts,odontoblasts,endothelial cells, and nerve cells), but SHEDs also possess immunomodulatory and immunosuppressive properties. The collagen matrix is a material of choice to provide structural and microenvironmental support for SHED-to-dentin pulp tissue differentiation. Growth factors regulate cell proliferation, migration, and differentiation into specific phenotypes via signal-transduction pathways. This review provides current concepts and applications of the tissue engineering approach, especially SHEDs,in endodontic treatment.

Item Type:	Article
Contributors:	Contribution Contributors NIDN/NIDK Email UNSPECIFIED Sugiaman, Vinna Kurniawati UNSPECIFIED UNSPECIFIED UNSPECIFIED Djuanda, Rudy UNSPECIFIED UNSPECIFIED UNSPECIFIED Pranata, Natallia UNSPECIFIED UNSPECIFIED UNSPECIFIED Naliani, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Delmolsky, Wayan L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jeffrey, Jeffrey UNSPECIFIED UNSPECIFIED
Uncontrolled Keywords:	dentin-pulp complex regeneration; signalling molecules; stem cell from human exfoliated deciduous teeth(SHED); tissue engineering
Subjects:	R Medicine > RK Dentistry
Depositing User:	Perpustakaan Maranatha
Date Deposited:	25 Nov 2023 03:21
Last Modified:	10 Dec 2023 17:24
URI:	http://repository.maranatha.edu/id/eprint/32356

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