Hippo Pathway Effectors YAP and TAZ and Their Association with Skeletal Muscle Ageing

Setiawan, Iwan and Sanjaya, Ardo and Lesmana, Ronny and Yen, Paul M. and Goenawan, Hanna (2021) Hippo Pathway Effectors YAP and TAZ and Their Association with Skeletal Muscle Ageing. Journal of Physiology and Biochemistry, 77 (1). pp. 63-73. ISSN 1138-7548

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Abstract

Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway’s influence on myogenesis and satellite cell functions, on supporting cells such as fibroblasts, and autophagy. YAP/TAZ was found to regulate both myoblast proliferation and differentiation, albeit with unique roles. Additionally, YAP/TAZ has different functions depending on the expressing cell type, making simple inference of their effects difficult. Studies in cancers have shown that the Hippo pathway influenced the autophagy pathway, although with mixed results. Most of the present researches on YAP/TAZ are focused on its oncogenicity and further studies are needed to translate these findings to physiological ageing. Taken together, the modulation of YAP/TAZ or the Hippo pathway in general may offer potential new strategies for the prevention or treatment of ageing.

Item Type: Article
Contributors:
ContributionContributorsNIDN/NIDKEmail
UNSPECIFIEDSetiawan, IwanUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDSanjaya, ArdoUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDLesmana, RonnyUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDYen, Paul M.UNSPECIFIEDUNSPECIFIED
UNSPECIFIEDGoenawan, HannaUNSPECIFIEDUNSPECIFIED
Uncontrolled Keywords: Yes-associated protein; Sarcopenia; Ageing; Skeletal muscle; Cell signalling
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 13 Jul 2023 07:36
Last Modified: 13 Jul 2023 07:36
URI: http://repository.maranatha.edu/id/eprint/31996

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