Ratnawati, Hana and Widyaputra, Sunardhi and Hernowo, Bethy S. and Kintawati, Silvi (2009) Increased Ki-67 expression in complete hydatidiform mole as a prediction factor of choriocarcinoma. In: International Seminar and Workshop on Modern Biology and its application: Focusing on Stem Cells and Human Genetics, 28-30 November 2009, Semarang.
|
Text
5. Prosiding Internasional_Stem cells and human genetics.pdf - Published Version Download (991Kb) | Preview |
Abstract
Background: The incidence of hydatidiform moles in Indonesia is about 11.6 % per 1000 pregnancies and between 10 % – 50% will develop to choriocarcinoma, a highly malignant neoplasm of trophoblastic cells with poor prognosis. Based on histopathological pattern, complete hydatidiform mole could differentiate to complete mole hydtidiform with less trophoblast proliferation (LTP) and complete hydatidiform mole with high trophoblast proliferation (HTP). Choriocarcinoma usually develop from complete hydatidiform mole as early as 7 days, or it may take up to 3 years to develop, but generally choriocarcinoma begins in the first year. The prognosis depends on the fast treatment on the early stage, that’s why it is important to find a biological marker which could predict the development of malignancy in hydatidiform mole. Ki-67 antigen is a nuclear marker of cell proliferation. Several studies showed that a high Ki-67 expession is associated with a greater risk for tumor development. Objective: To investigate the role of Ki-67 immunoexpression in predicting the malignancy progress of complete hydatidiform mole. Methods: Formalin fixed, paraffin embedded tissue biopsies from patients with complete hydatidiform moles LPT (n = 15), HPT (n = 17) and choriocarcinoma (n = 15) were studied for Ki-67 expression by immunohistochemistry. Each slide was scored based on the percentage of positively stained malignant nuclei. The following ranges were used for the proliferative index: < 40% (very low), 40% to 60% (low), 61% to 80% (intermediate), and > 80% (high). The data was analyze by ANAVA and Duncans. Results: The Ki-67 expression of complete hydatidiform mole with LPT, showed very low (46.6%) and low (53.3%) proliferative index, however in complete hydatidiform moles HPT, 29.4% low, 52.9% intermediate and 17.3% very high proliferative index. In choriocarcinoma mostly (86.6%) showed high proliferative index, while only 13.3% with intermediate proliferative index. There was a highly significant difference of proliferative index between complete hydatidiform mole LPT and HPT (p<0.001) and between complete hydatidiform mole LPT with choriocarcinoma (p<0.001). Conclusion: The high immunoexpression of Ki-67 can predict choriocarcinoma following complete hydatidiform mole with the Odds Ratio 30.33 times.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | complete hydatidiform mole, choriocarcinoma, Ki-67 immunoexpression |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 22 Mar 2022 03:23 |
| Last Modified: | 22 Mar 2022 03:23 |
| URI: | http://repository.maranatha.edu/id/eprint/30164 |
Actions (login required)
 |
View Item |
