Ratnawati, Hana and Chornelia, Demes and Felim, Steven (2021) Factors that Influenced the Covid-19 Antibody Titer Post-Vaccination. In: International Webinar Covid-19 Pandemic: Impacts, Strategies, and Challenges on the Urban Health, 3-4 September 2021.
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Oral Presentation_Factors that influenced the Covid-19 antibody titer post-vaccination_International Webinar.pdf Download (1330Kb) | Preview |
Abstract
Introduction: As of 8 August 2021, almost 24 million doses of Covid-19 vaccines have been administered in Indonesia and have covered 11,4% of the Indonesian population with two doses vaccines. The first Covid-19 vaccine used in Indonesia was the inactivated SARS-CoV-2 vaccine with aluminum hydroxide adjuvant, known as CoronaVac produced by Sinovac Biotech Ltd., Beijing, China, with the efficacy in Indonesia was 65,3%. SARS-CoV-2 as the cause of Covid-19, is a single-stranded RNA virus, which has an envelope, membrane, nucleocapsid and spike glycoprotein (S). This spike protein consists of S1 subunits with the Receptor Binding Domain (RBD) and S2 subunit. The RBD protein has a strong affinity with ACE-2 receptor in the host cells and will mediates the entry of the virus. The purpose of this study was to analyze the vaccine recipient-related factors that influence the antibodies post-Covid-19 vaccination titer. Methods: Participants were healthy adults with no history of Covid-19, have been received two doses of CoronaVac, with intramusculair injection. Exclusion criteria include immunosuppressive therapy, received of any blood products or immunoglobulins and bleeding disorders within the past 3 months. Quantitative antibody specific for the RBD of the SARS-CoV-2 spike protein was measured between 28-30 days after the second vaccination with ELISA Anti SARS-CoV-2-S RBD protein assay and was carried out at Prodia Clinical Laboratory. Data were analyzed using Mann-Whitney non-parametric test and Pearson correlation to analyze the correlation between BMI and antibody titer. Result: All participants (20 men and 16 women) showed reactive antibody results with the lowest titer was 1.51 U/mL and the highest titer above 250 U/mL. Participants over 45 years age showed lower antibody titers (58,18 U/mL) compared to the young adult group below 45 years age (85,94 U/mL). Gender also showed differences, men (61,47 U/mL) showed lower antibody titers than women (87,02 U/mL). Participants with obese (BMI >25.00 kg/m2) has lower antibody titers (56,04 U/mL) compared to normal BMI (82,32 U/mL). Antibody titers were almost identical between those with comorbidities (73,24 U/mL) and those without comorbidities (72,50 U/mL). However, statistically, these factors were not significantly different (p>0,05). Pearson correlation coefficient -0.206 means a negative correlation between BMI and antibody titer, but the relationship is weak. Conclusion: Factors related to vaccine recipients that affect Covid-19 antibody titers are gender, age, and obesity. There is an inverse correlation between BMI and Covid-19 titer antibody post vaccination.
| Item Type: | Conference or Workshop Item (Paper) |
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| Uncontrolled Keywords: | Covid-19, titer antibody post-vaccination, gender, age, basal metabolic index |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 15 Mar 2022 09:57 |
| Last Modified: | 15 Mar 2022 10:02 |
| URI: | http://repository.maranatha.edu/id/eprint/30148 |
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