Utami, Sri and Adityaningsari, Pratami and Sosiawan, Insan and Endrini, Susi and Sachrowardi, Qomariyah Romadhiyani and Laksono, Sonny Pamuji and Nafik, Said and Arrahmani, Cendera Arrahmani and Afifah, Ervi and Widowati, Wahyu (2017) Antioxidants and Anticholinesterase Activities of the Characterized Ethanolic of Ripe Sesoot (Garcinia picrorrhiza Miq.) Fruit Extract (GpKar) and Xanthone. Traditional Medicine Journal, 22 (3). pp. 160-165. ISSN 1410-5918
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PR 38. Antioxidants and Anticholinesterase Activities of the Characterized Ethanolic of Ripe Sesoot (Ga.pdf Download (537Kb) | Preview |
Abstract
Oxidative stress has been known to contribute to Alzheimer’s disease. Acetylcholinesterase (AChE) enzyme may lead to Alzheimer’s disease as a neurotransmitter. Antioxidants may have protective activities against oxidative damage and Alzheimer’s disease. Acetylcholinesterase inhibitors also can be used in the treatment of various neurological disorders for management of Alzheimer’s disease. This study aimed to determine antioxidant and anticholinesterase effects of Garcinia picrorrhiza Miq. fruit extract (GpKar) and its compounds, xanthone. Antioxidant activity was measured by H2O2 scavenging inhibitory activity, while anticholinesterase activity was measured using modified Ellman method. GpKar has higher H2O2 scavenging inhibitory activity (IC50= 967.28 μg/ml) compared to xanthone (IC50= 1198.95 μg/ml). In the anticholinesterase inhibitory activity, GpKar has lower activity (IC50= 70.25 μg/ml) compared to xanthone (11.80 μg/ml). In summary, GpKar has higher antioxidant activity but lower anticholinesterase activity compared to its compounds, xanthone. However, GpKar has potency as antioxidant agent to prevent Alzheimer’s disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GpKar; xanthone; antioxidant; anticholinesterase |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 16 Jun 2021 10:33 |
| Last Modified: | 14 Jul 2021 02:12 |
| URI: | http://repository.maranatha.edu/id/eprint/27648 |
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