Widowati, Wahyu and Jasaputra, Diana Krisanti and Heriady, Yusuf and Faried, Ahmad and Rizal, Rizal and Widodo, Wahyu Setia and Wibowo, Satrio Haryo Benowo and Kusuma, Hanna Sari W. and Girsang, Ermi and Lister, I Nyoman Ehrich (2019) Dietary Flavonoids Against Various Breast Cancer Subtypes: a Molecular Docking Study. Science Asia, 45 (5). pp. 452-457. ISSN 1513-1674
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40. Turnitin_Dietary flavonoids against various breast cancer subtypes a molecular docking study.pdf Download (2082Kb) | Preview |
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Abstract
ABSTRACT: Breast cancer is female most frequent diagnosed cancer and the leading cause of cancer death. The consumption of dietary flavonoids is reported to cause significant breast cancer risk reduction. In vitro studies often used aglycone flavonoids rather than its conjugated form that actually present in human body. Thus its mechanism against breast cancer has not been elucidated completely. The present study aimed to investigate the possible mechanism of dietary flavonoids against breast cancer by in silico study. Conjugated flavonoids were docked to ER (estrogen receptor), HER2 (human epidermal growth factor receptor 2) and EGFR (epidermal growth factor receptor) kinase domains. The molecular docking of 22 flavonoid conjugates towards EGFR and HER2 kinase domain, and ER was successfully performed. Potential binders to proteins: epicatechin conjugates to ER (
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | molecular docking simulation, diet, flavonoids, antineoplastic agents, breast neoplasms |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 06 Oct 2020 06:07 |
| Last Modified: | 15 Nov 2022 05:26 |
| URI: | http://repository.maranatha.edu/id/eprint/27383 |
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