Girsang, Ermi and Ginting, Chrismis Novalinda and I Nyoman, Ehrich Lister and Widowati, Wahyu and Wibowo, Satrio Haryo Benowo and Perdana, Fajar Sukma and Rizal, Rizal (2019) In silico analysis of phytochemical compound found in snake fruit (Salacca zalacca) peel as anti-aging agent. Thai Journal of Pharmaceutical Sciences, 43 (2). pp. 105-109.
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Abstract
Background: Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function of the skin. Snake fruit (Salacca zalacca) is an important fruit crop native from Indonesia. Its waste is a potential source bioactive phytochemical compound. Objectives: Present study investigates possible anti-aging potency of phytochemical compound found in salak fruit peel based on its binding towards enzyme related in skin aging process. Materials and Methods: Molecular docking was performed towards enzyme subjected to degradation of dermal matrix (MMP1, NEP) and hyper-pigmentation (PPO3). Results: Docked compound occupied the active site of each protein in which chlorogenic acid has the highest affinity among salak peel compound against MMP1, and Rutin against NEP and PPO3. Further intermolecular analysis revealed favourable interaction between chlorogenic acid, rutin towards respective protein. Conclusions: Taken together compound found in snake fruit, display possible inhibition towards protein related in skin aging and could be potentially used as anti-aging agent.
| Item Type: | Article |
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| Uncontrolled Keywords: | Aging, molecular docking simulation, phytochemicals, Salacca zalacca, skin |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > 10 School of Medicine |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 29 Oct 2019 01:01 |
| Last Modified: | 29 Oct 2019 01:01 |
| URI: | http://repository.maranatha.edu/id/eprint/27083 |
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