The Comparison Effect of Aloe vera L., Psidium guajava Linn, Curcuma domestica Val to Colitis Ulcerative Mice Model Histopatology

Kurniawati, Dewi and Jasaputra, Diana Krisanti and Ratnadewi, Hana and Tiono, Hartini and Sujatno, Muchtan and Dewi, Aprilin Krista and S., Putu Mayestica and Arifin, Samuel (2010) The Comparison Effect of Aloe vera L., Psidium guajava Linn, Curcuma domestica Val to Colitis Ulcerative Mice Model Histopatology. Jurnal Medika Planta, 1 (2). pp. 41-48. ISSN 2086-7514

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Abstract

Introduction: Ulcerative colitis (UC) is an inflammatory disease limited to the mucosa/ and submucosal layers of the colon. UCtreatments was aimed to decrease inflammation and oxidation process on colon. Nowadays people start using herbal medicine to attenuate inflammation and oxidation process in ulcerative colitis, e.g. Aloe vera, Psidium guajava Linn, Curcuma domestica Val. Objective: to compare the effect of Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract on histopatology of ulcerative colitis. Methods : experimental comparative research with completely randomized design. Mice were divided on 5 groups (n=6) which were given Aloe vera ethanol extract 700 mg/kgBB and DSS 2,5%; Psidium guajava Linn ethanol extractl.591,2 mglkgBB and DSS 2,5%; Curcuma domestica Val ethanol extract 180.816 mglkgBB and DSS 2,5%; aquadest and DSS 2,5% (positive control); aquadest (negative control). Data were analyzed with ANO VAfollowed by Tukey HSD test with a=O,05. Results: there were a decrementpercentage of crypt loss on Aloe vera ethanol extract group (10.5 ± 4,64681 %), Psidium guajava Linn ethanol extract group (1I ± 2,09762 %), Curcuma domestica Val ethanol extract group (9 ± 3,09839 %) compared with positive control group (26.8 ± 1,72240 %)(p<0,05). Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract had same effectivity (p>0,05). Conclusion : Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Valethanol extract had same effectivity on decreasingpercentage of crypt loss on colitis ulcerative histopatology of mice induced by DSS 2.5%.

Item Type:	Article
Uncontrolled Keywords:	Ulcerative colitis, Aloe vera L, Psidium guajava Linn, Curcuma domestica Val
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Perpustakaan Maranatha
Date Deposited:	16 Apr 2018 09:14
Last Modified:	16 Apr 2018 09:14
URI:	http://repository.maranatha.edu/id/eprint/24351

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