The Comparison of Effect between Water and Ethanol Extract of Meniran Herb on the Amount of Eosinophil Percentage in Atopic Dermatitis Mice Model

Jasaputra, Diana Krisanti and Santosa, Slamet and Sujatno, Muchtan and Dylan, Rhenata (2010) The Comparison of Effect between Water and Ethanol Extract of Meniran Herb on the Amount of Eosinophil Percentage in Atopic Dermatitis Mice Model. Jurnal Medika Planta, 1 (1). pp. 49-56. ISSN 2086-7514

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Abstract

Introduction: Atopic dermatitis is hypersensitivity reaction type I which isfollowed by the increasing of eosinophil, which has role in pathogenesis chronic allergic inflammation. One of the treatment target of atopic dermatitis is to decrease the amount of eosinophil, so the inflammation reaction decreased. Meniran herb is usually used by community to treat dermatitis. The aim of this research is tofind out the effect of water and ethanol extract of meniran herb (Phyllanthus niruri. L) to the amount of eosinophil percentage. Methods: The experimental preclinic research in laboratorium is longitudinal, prospective, and comparatives. The mice that induced allergy with ovalbumin were divided randomly in groups (n=6). Various doses of water and ethanol extract meniran herb were given to those groups, then compared to the group which is given the ovalbumin only (controlpositive). The experimental data of the amount of eosinophil percentage was analyzed by ANO VA, whichfollowed by the Duncan test, with a=0,05. Results: the researchproved that decreasing of the amount of eosinophilpercentage doses 1, 2, 3, 4, water meniran extract consecutively 34.833%, 16.167%, 22.833%, 27.833% whereas doses 1, 2, 3, 4, etanol meniran extract consecutively 31.167%, 21.667%,35.167%, 25.833% compared with the positive control (46.833%) (p<0,05). Water and ethanol extract have the same maximum ejfectivity at dose 2 (p>0,05). Conclusion: meniran herb water and ethanol extract have same effect in decreasing the amount of eosinophil percentage.

Item Type: Article
Uncontrolled Keywords: atopic dermatitis, eosinophil, meniran herb
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 16 Apr 2018 08:15
Last Modified: 16 Apr 2018 08:15
URI: http://repository.maranatha.edu/id/eprint/24343

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