Widowati, Wahyu and Rihibiha, Dwi Davidson and Khiong, Khie and Widodo, M. Aris and Sumitro, Sutiman B. and Bachtiar, Indra (2017) Hypoxia in Mesenchymal Stem Cell 91. In: Hypoxia and Human Diseases. Intech, pp. 91-115. ISBN 978-953-51-2896-0
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Abstract
Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent stem cells with selfrenewal properties and ability to differentiate into a variety of mesenchymal tissues. This chapter overviews effects of hypoxia on MSCs, makes it promising therapy to various diseases. Cultivation of MSCs under hypoxic condition results in variety of outcome that is important to be noted in clinical use. In most studies, hypoxic condition appears to increase proliferation, differentiation, and immune regulatory performance of MSCs without affecting its characteristic. Those benefits are therefore utilized in clinical application. However, there are also studies that report on negative effects of hypoxia in MSCs such as chromosomal instability. Molecular mechanism of MSCs in hypoxic condition is provided for better understanding, which is crucial for further development with better outcome.
| Item Type: | Book Section |
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| Uncontrolled Keywords: | mesenchymal stem cells, hypoxia |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 27 Feb 2017 08:32 |
| Last Modified: | 27 Feb 2017 08:32 |
| URI: | http://repository.maranatha.edu/id/eprint/21766 |
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