In-vitro Study of Potential Antioxidant Activities of Mangosteen and Its Nanoemulsions

Widowati, Wahyu and Wargasetia, Teresa Liliana and Sugiaman, Vinna K. and Rachmaniar, Revika and Yuninda, Viranda Andria and Sabrina, Adilah Hafizha Nur and Azizah , Anis Suci and Legowo, Wahyu Priyo and Ferdiansyah, Rival (2023) In-vitro Study of Potential Antioxidant Activities of Mangosteen and Its Nanoemulsions. Medical Plants, 15 (3). pp. 534-542. ISSN 0975=6892

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Abstract

Reactive Oxygen Species (ROS) are the major key component in cellular processes and participate in vital functions within cell signaling pathways, regulation of gene expression, and cellular metabolism. Mangosteen peel, rich in powerful antioxidants to prevent oxidative damage due to ROS, is believed to have potential health benefits. Nanoemulsion, a liquid dispersion with small droplets, can have significant applications in drug delivery due to their enhanced bioavailability and stability so which can be used to optimize the application of mangosteen peel extract. The aim of this research is to examine and compare the antioxidant potential of mangosteen peel compound and nanoemulsion (Garcinia mangostana L.). The mangosteen peel nanoemulsion was characterized by analysis using particle size analysis, zeta potential analysis and transmission electron microscopy. The antioxidant activity of several Mangosteen Nanoemulsion (MN) and isolate (MI) concentrations were analyzed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6- sulfonic acid) diammonium salt (ABTS), hydrogen peroxide (H2O2), nitric oxide (NO), and ferric reducing antioxidant power assays (FRAP). MN can be formulated and the average particle size of MN was 200.9 nm. The average zeta potential of MN was -69.36 mV. MN also has strong antioxidant activity. MI has higher antioxidant activities than MN. This study shows that the stability of MN and its potential as an antioxidant can be studied further in the field of pharmaceutical formulations.

Item Type: Article
Contributors:
ContributionContributorsNIDN/NIDKEmail
UNSPECIFIEDWidowati, WahyuUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDWargasetia, Teresa LilianaUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDSugiaman, Vinna K.UNSPECIFIEDUNSPECIFIED
UNSPECIFIEDRachmaniar, RevikaUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDYuninda, Viranda AndriaUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDSabrina, Adilah Hafizha NurUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDAzizah, Anis SuciUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDLegowo, Wahyu PriyoUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDFerdiansyah, RivalUNSPECIFIEDUNSPECIFIED
Uncontrolled Keywords: Antioxidant, Garcinia mangostana L., nanoemulsions
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 03 Dec 2023 22:51
Last Modified: 10 Dec 2023 17:45
URI: http://repository.maranatha.edu/id/eprint/32373

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