Christoper, Andreas and Herman, Herry and Abdulah, Rizky and Zuhendri, Felix and Sanjaya, Ardo and Lesmana, Ronny
(2023)
Physiological Roles of Hippo Signaling Pathway and Autophagy in Dementia.
Current Aging Science, 16 (2).
pp. 112-124.
ISSN 1874-6098
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6. Physiological Roles of Hippo Signaling Pathway and Autophagy in Dementia _ Bentham Science-merged.pdf
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Abstract
Background: Dementia is a neurocognitive disorder associated with the aging brain and mainly
affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy
proteins have been found to be perturbed in the brain affected by dementia processes.
Objective: This systematic review aims to elaborate on the involvement of the Hippo signaling
pathway and autophagy in modulating the progression and severity of dementia in aging.
Methods: Searches were conducted on MEDLINE, Google Scholar, Scopus, and Web of Science
databases.
Results: The Hippo signaling pathway is dependent upon the transcriptional co-activator
YAP/TAZ, which forms complexes with TEAD in the nucleus in order to maintain cell
homeostasis. When the expression YAP/TAZ is reduced, transcriptional repression-induced
atypical cell death, ballooning cell death, and necrosis will consequently occur in the neurons.
Moreover, the autophagic proteins, such as LC3, ATG proteins, and Beclin, are reduced,
resulting in the disruption of autophagosome formation and accumulation and the spread of
misfolded proteins in the brain suffering from dementia.
Conclusion: The impairment of the Hippo signaling pathway and autophagy in the dementia
process in aging should be considered since it might predict the severity, treatment, and
prevention of dementia.
| Item Type: |
Article
|
| Contributors: |
| Contribution | Contributors | NIDN/NIDK | Email |
|---|
| UNSPECIFIED | Christoper, Andreas | UNSPECIFIED | UNSPECIFIED | | UNSPECIFIED | Herman, Herry | UNSPECIFIED | UNSPECIFIED | | UNSPECIFIED | Abdulah, Rizky | UNSPECIFIED | UNSPECIFIED | | UNSPECIFIED | Zuhendri, Felix | UNSPECIFIED | UNSPECIFIED | | UNSPECIFIED | Sanjaya, Ardo | UNSPECIFIED | UNSPECIFIED | | UNSPECIFIED | Lesmana, Ronny | UNSPECIFIED | UNSPECIFIED |
|
| Uncontrolled Keywords: |
aging; autophagy; brain; dementia; Hippo signaling pathway; neurogeneration |
| Subjects: |
R Medicine > R Medicine (General) |
| Depositing User: |
Perpustakaan Maranatha
|
| Date Deposited: |
13 Jul 2023 07:55 |
| Last Modified: |
13 Jul 2023 09:39 |
| URI: |
http://repository.maranatha.edu/id/eprint/31999 |
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