Detam 1 Black Soybean Against Cisplatin-Induced Acute Ren Failure on Rat Model via Antioxidant, Antiinflammatory and Antiapoptosis Potential

Widowati, Wahyu and Prahastuti, Sijani and Hidayat, Meilinah and Hasianna, Stella Tinia and Wahyudianingsih, Roro and Eltania, The Fransiska and Azizah, Alya Mardhotillah and Aviani, Jennifer Kiem and Subangkit, Mawar and Handayani, Rr. Anisa Siwianti and Kusuma, Hanna Sari Widya (2022) Detam 1 Black Soybean Against Cisplatin-Induced Acute Ren Failure on Rat Model via Antioxidant, Antiinflammatory and Antiapoptosis Potential. Journal of Traditional and Complementary Medicine.

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Abstract

Background and aim: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean (Glycine max L. merr.) has been reported contain high levels of phenolics and anthocyanins that has antioxidant activity. This study aims to determine the effect of ethanol extract of black soybean (EEBS) against cisplatin-induced nephrotoxicity in rats. Experimental procedure: Cisplatin-induced nephrotoxicity rats treated with EEBS and the blood samples taken on days 0, 9, and 18. The effects of EEBS was evaluated by determining Interferon-g (IFN-g), Caspase-3 (Casp-3), and Interleukin-1b (IL-1b) expression using immunohistochemistry (IHC), blood urea nitrogen (BUN), Uric Acid (UA) content and catalase (CAT) content in the blood plasma with colorimetric assay kit. Results and conclusion: Based on the results, EEBS treatment had successfully reduced pro-inflammatory cytokines IL-1b and IFN-g, and improved physiological condition by lowering BUN and UA content while increasing CAT activity. No significant effect was found in Casp-3 expression. EEBS has potential to improve acute renal failure condition through inflammatory suppression and renal function improvement.

Item Type: Article
Uncontrolled Keywords: blood urea nitrogen; catalase; firbronectin; glycine max L. Merr.; Nephrotoxicity
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 24 Mar 2022 08:36
Last Modified: 24 Mar 2022 08:36
URI: http://repository.maranatha.edu/id/eprint/30190

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