Girsang, Ermi and Ginting, Chrismis N. and Lister, I Nyoman Ehrich and Gunawan, Kamila Yashfa and Widowati, Wahyu (2021) Anti-inflammatory andantiaging properties ofchlorogenicacidon UV-induced fibroblast cell. PeerJ-Life & Environment.
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Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell.pdf Download (9Mb) | Preview |
Abstract
Background: Skin agingisthemostcommondermatologicalproblemcausedby intrinsic andextrinsicfactor,suchasexposureto(ultraviolet)UVrays.Chlorogenic acid (CA)isaphenoliccompoundwhichisknownforitsantioxidantproperties against oxidativestress. Objective: This studyinvestigatestheantiagingandanti-inflammatory propertiesof CA onUV-inducedskin fibroblast cells. Methods: Anti-inflammatory propertiesofCAwereassessedbymeasuring inflammatory-relatedproteinsIL-1β and TNF-a, whileantiagingpropertiesofCA were assessedbymeasuringreactiveoxygenspecies(ROS),apoptosis,liveand necrotic cells,andCOL-3geneexpressionlevel. Results: Treating UV-inducedskin fibroblast cellswithCAdecreasedthelevelof ROS, IL-1β, TNF-a, apoptoticcells,andnecroticcellsandincreasedlivecellsand COL-3 geneexpression. Conclusion: CA hasthepotentialastheprotectivecompoundagainstinflammation and agingbydecreasingthelevelROS,pro-inflammatory cytokinesIL-1β and TNF-a, apoptoticcells,andnecroticcellsandbyincreasinglivecellsandCOL-3gene expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Antiaging,Anti-inflammatory,Apoptosis,Chlorogenicacid,Ultraviolet |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 15 Sep 2021 02:32 |
| Last Modified: | 05 Nov 2021 08:52 |
| URI: | http://repository.maranatha.edu/id/eprint/27819 |
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