Free Radical Scavenging Activity of Ethanolic Leaves Extract and Its Different Solvent Fractions of Piper betle L. In Vitro

Risdian, Chandra and Widowati, Wahyu and Mozef, Tjandrawati and Wargasetia, Teresa L. and Khie Khiong, - (2011) Free Radical Scavenging Activity of Ethanolic Leaves Extract and Its Different Solvent Fractions of Piper betle L. In Vitro. Indonesian Journal of Cancer Chemoprevention, 2 (1). pp. 141-145. ISSN 2088-0197

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Abstract

Various diseases including cancer and cardiovascular diseases are induced by free radical via lipid perioxidation, protein peroxidation, DNA damage, and cellular degeneration in the cells. Piper betle L., commonly called betel, belongs to the Piperaceae family. It originated from South and South East Asia, and has been used as a traditional medicine by people there due to its medical properties. In the present study, free radical scavenging activity of ethanolic leaves extract of Piper betle L. together with its different solvent fractions (hexane, ethyl acetate, butanol and water) were evaluated by DPPH free radical scavening assay. The ethanolic extract and the ethyl acetate fraction had shown to the other fractions. In DPPH free radical scavenging assay, the ICse value of the ethanolic extract and the ethyl acetate fraction were found to be 17.43mg/mL. and 11.53 mg/mL., respectively. The free radical scavenging activity was assumed due to the total phenolic content. The total phenolic content was found to be highest in the ethanol extract (277.68 mg EGCG/mg) and the ethyl acetate fraction (559.38 mg EGCG/mg). The results concluded that the ethanolic leaves extract of Piper betle L. and its ethyl acetate fraction have a considerably free radical scavening activity.

Item Type: Article
Uncontrolled Keywords: piper betle L., Piperaceae, free radical scavenging, DPPH
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Perpustakaan Maranatha
Date Deposited: 15 Jul 2013 04:49
Last Modified: 15 Jul 2013 04:49
URI: http://repository.maranatha.edu/id/eprint/3732

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