Efek Antijamur Ekstrak n-Heksana dan Etil Asetat Daun Saga (Abrus precatorius Linn.) dalam Menghambat Pertumbuhan Candida albicans

Ester, Sisca and Naliani, Silvia and Sugiaman, Vinna K. (2025) Efek Antijamur Ekstrak n-Heksana dan Etil Asetat Daun Saga (Abrus precatorius Linn.) dalam Menghambat Pertumbuhan Candida albicans. e-Gigi, 13 (2). pp. 305-311. ISSN 2338-199X

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Abstract

Candida albicans is an opportunistic fungus that causes soft tissue infections in the oral cavity known as denture stomatitis, often experienced by removable denture wearers. Good denture hygiene can prevent the growth of this Candida albicans. Treatment using herbal plants is now increasingly being used, such as saga leaves, due to its potentisal antifungal activity. Saga leaves contain secondary metabolite compounds such as flavonoids, alkaloids, tannins, saponins, quinones, steroids/terpenoids. These active compounds have antifungal activity. This study aimed to determine the antifungal effect of n-Hexane and ethyl acetate extracts of saga leaves in inhibiting Candida albicans. This study used the Kirby-Bauer disc diffusion method with several concentrations: 50%, 25%, 12.5%, 6.25%, 3.125%, and 1.625%. The results showed that the ethyl acetate extract of saga leaves at a concentration of 50% had the highest value with a mean diameter zone of inhibition of 8.15 mm (medium category), meanwhile, n-Hexane extract of saga leaves at a concentration of 50% had a mean diameter zone of inhibition of 1.20 mm. In conclusion, the ethyl acetate extract of saga leaves can inhibit the growth of Candida albicans.

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