Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging

Limyati, Yenni and Sanjaya, Ardo and Lucretia, Teresa and Gunadi, Julia Windi and Biben, Vitriana and Jasaputra, Diana Krisanti and Lesmana, Ronny (2022) Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging. Current Cardiology Reviews, 18 (5). pp. 24-33. ISSN 1875-6557

Text 4. Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging.pdf Download (23Mb)

Abstract

Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ.

Item Type:	Article
Contributors:	Contribution Contributors NIDN/NIDK Email UNSPECIFIED Limyati, Yenni UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanjaya, Ardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucretia, Teresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Gunadi, Julia Windi UNSPECIFIED UNSPECIFIED UNSPECIFIED Biben, Vitriana UNSPECIFIED UNSPECIFIED UNSPECIFIED Jasaputra, Diana Krisanti UNSPECIFIED UNSPECIFIED UNSPECIFIED Lesmana, Ronny UNSPECIFIED UNSPECIFIED
Uncontrolled Keywords:	Aging; TAZ; YAP; cardiac hypertrophy; cardiomyocyte; exercise
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Perpustakaan Maranatha
Date Deposited:	13 Jul 2023 07:44
Last Modified:	13 Jul 2023 07:44
URI:	http://repository.maranatha.edu/id/eprint/31997

Actions (login required)

View Item