The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats

Gunadi, Julia Windi and Jasaputra, Diana Krisanti and Gunawan, Decky and Edwinanto, Ludovicus and Kwee, Limdawati and Pramono, Harijadi and Suhendra, Adrian and Sariwidyantry, Ghita and Goenawan, Hanna and Lesmana, Ronny (2021) The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats. In: 1st International Conference on Emerging Issues in Technology, Engineering and Science, Bandung, July 1-2, 2021.

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Abstract

Fibroblast growth factor 23 (FGF23) acts as a hormone that regulates phosphate metabolism associated with kidney function, and an inducer of left ventricle hypertrophy. But the role of FGF23 as a myokine has not yet to be confirmed. This research aims to investigate the effect of different intensities of treadmill exercise on FGF23 gene expression in gastrocnemius and soleus muscles of Wistar rats. Twenty male Wistar rats were given different intensities of treadmill exercise (low, moderate, and high) for as long as 8 weeks. FGF23 gene expression in gastrocnemius and soleus muscles was examined using semi-quantitative PCR. In this study, we obtained no change of relative FGF23 mRNA expression in gastrocnemius muscles (p = 0.684) compared to control. But interestingly, we found a significant increase of relative FGF23 mRNA expression in soleus muscles (p = 0.030). These results showed that different intensities of treadmill exercise do not stimulate FGF23 gene expression in gastrocnemius muscles of Wistar rats. While the low intensity of treadmill exercise does not increase FGF23 relative mRNA expression, moderate and high intensities of treadmill exercise increase FGF23 gene expression in the Wistar rat’s soleus muscles.

Item Type:	Conference or Workshop Item (Paper)
Contributors:	Contribution Contributors NIDN/NIDK Email UNSPECIFIED Gunadi, Julia Windi UNSPECIFIED UNSPECIFIED UNSPECIFIED Jasaputra, Diana Krisanti UNSPECIFIED UNSPECIFIED UNSPECIFIED Gunawan, Decky UNSPECIFIED UNSPECIFIED UNSPECIFIED Edwinanto, Ludovicus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kwee, Limdawati UNSPECIFIED UNSPECIFIED UNSPECIFIED Pramono, Harijadi UNSPECIFIED UNSPECIFIED UNSPECIFIED Suhendra, Adrian UNSPECIFIED UNSPECIFIED UNSPECIFIED Sariwidyantry, Ghita UNSPECIFIED UNSPECIFIED UNSPECIFIED Goenawan, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Lesmana, Ronny UNSPECIFIED UNSPECIFIED
Uncontrolled Keywords:	FGF23, Treadmill Exercise, Gastrocnemius, Soleus
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Perpustakaan Maranatha
Date Deposited:	27 Apr 2023 22:58
Last Modified:	27 Apr 2023 22:58
URI:	http://repository.maranatha.edu/id/eprint/31841

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