Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Ginting, Chrismis Novalinda and Lister, I Nyoman Ehrich and Girsang, Ermi and Mutia, Maya Sari and Lubis, Yolanda Eliza Putri and Amalia, Annisa and Widodo, Wahyu Setia and Artie, Dwi Surya and Rizal, Rizal and Widowati, Wahyu (2021) Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926. Journal of Mathematical and Fundamental Sciences, 53 (3). pp. 487-496. ISSN 2337-5760

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Abstract

Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 μg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p < 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.

Item Type: Article
Uncontrolled Keywords: EA.hy926; Ficus elastica; hypoxia; IL-10; preeclampsia; TNF-α.
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 24 Mar 2022 07:43
Last Modified: 24 Mar 2022 07:43
URI: http://repository.maranatha.edu/id/eprint/30184

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