Widowati, Wahyu and Tjokropranoto, Rita and Wahyudianingsih, Roro and Tih, Fen and Sadeli, Lisawati and Kusuma, Hanna Sari Widya and Fuad, Nerissa Arviana and Girsang, Ermi and Agatha, Faustina Audrey (2021) Antidiabetic Potential Yacon (Smallanthus sonchifolius (Poepp.) H. Rob.) Leaf Extract via Antioxidant Activities, Inhibition of α-glucosidase, α- amylase, G-6-Pase by In Vitro Assay. Journal of Reports in Pharmacetical Sciences, 10 (2).
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Abstract
Diabetes is a chronic disease characterized by glucose levels and results in impaired insulin secretion. This disorder has triggered oxidative stress and excess free radicals condition. Smallanthus sonchifolius is a traditional medicine that acts as a diabetic therapy. This research aims to bring out the antidiabetic and antioxidant potential of S. sonchifolius extract (SSE). Materials and Methods: This study was conducted to measure the qualitative phytochemical identification, antioxidant and anti-diabetic activity of SSE. The antioxidant assay was carried out using 2,2-diphenyl-1-picrylhydrazine (DPPH)- scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-scavenging and hydrogen peroxide (H2O2)-reducing activity assays, ferric reducing antioxidant power (FRAP) potency, while anti-diabetic activity of SSE assay was carried out using inhibitory of α-amylase, α-glucosidase, and Glucose-6-Phosphatase (G-6-Pase). Results: SSE contained phenols, flavonoids, steroids/triterpenoids, saponins, tannins, and alkaloids. The antioxidant and antidiabetic activities of samples were calculated based on median inhibitory concentration (IC50). The IC50 values of SSE antioxidant, respectively, were DPPH (IC50 = 62.72 μg/mL), ABTS (IC50 = 61.03 μg/mL), H2O2 (IC50 = 438.36 μg/mL), the highest FRAP activity was 125.31 μM Fe(II)/μg extract at a concentration level of SSE 50 μg/mL. The IC50 values of SSE antidiabetic were α-amylase inhibition (IC50 = 37.86 μg/mL), α-glucosidase inhibition (IC50 = 90.41 μg/ mL), and G-6-Pase inhibition (IC50 = 98.07 μg/mL), respectively. Conclusions: SSE has antidiabetic potential through antioxidant activities and α-glucosidase, α-amylase, and G-6-Pase inhibition activities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Antioxidant, diabetes, Smallanthus sonchifolius, α-amylase, α-glucosidase |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 24 Mar 2022 07:35 |
| Last Modified: | 22 Nov 2022 02:16 |
| URI: | http://repository.maranatha.edu/id/eprint/30182 |
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