Chai, Yu Juan and Go, Younghoon and Zhou, Hai Qi and Li, Hong Xu and Lee, Sun Joo and Park, Yeo Jin and Widowati, Wahyu and Rizal, Rizal and Kim, Young Ho and Yang, Seo Young and Li, Wei (2021) Unusual Bicyclo[3.2.1]Octanoid Neolignans from Leaves of Piper crocatum and Their Effect on Pyruvate Dehydrogenase Activity. Plants, 10.
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Abstract
Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated using extensive spectroscopic analyses including 1D and 2D NMR experiments and HR-ESI-MS analysis, as well as through comparison with previously reported data. Two compounds were assessed for their inhibitory effect against pyruvate dehydrogenase E1� S300 phosphorylation. The fluorescent image suggested that both compounds (60 �M) revealed a stronger inhibition effect than the positive control (dichloroacetate, DCA 5 mM), with IC50 values of 99.82 �M and 80.25 �M, respectively.
| Item Type: | Article |
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| Uncontrolled Keywords: | Piper crocatum Ruiz & Pav; Piperaceae; antineoplastic cell agents; neolignan |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 24 Mar 2022 07:27 |
| Last Modified: | 24 Mar 2022 07:27 |
| URI: | http://repository.maranatha.edu/id/eprint/30181 |
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