Girsang, Ermi and Ginting, Chrismis Novalinda and Lister, I Nyoman Ehrich and Gunawan, Kamila Yashfa and Widowati, Wahyu (2021) Anti-inflammatory and Antiaging Properties of Chlorogenic Acid on UV-Induced Fibroblast Cell. PeerJ, 9 (2).
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61.Int Publikasi 2021-4 (Ermi PeerJ - Wahyu FKUKM) Reviewer.pdf Download (11Mb) | Preview |
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61. Turnitin_Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell.pdf Download (3287Kb) | Preview |
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Abstract
Background: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. Objective: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. Methods: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-a, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. Results: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-a, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. Conclusion: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-a, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
| Item Type: | Article |
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| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 24 Mar 2022 07:12 |
| Last Modified: | 14 Nov 2022 09:45 |
| URI: | http://repository.maranatha.edu/id/eprint/30179 |
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