Aloe vera Protective Effect on Lipopolysaccharide- Induced RAW 264.7 Inflamed Cells

Angelia, Ervina and Lokanata, Shieny and Widowati, Wahyu and Wijaya, Steven and Muttaqin, Zulfan and Florenly, Florenly (2021) Aloe vera Protective Effect on Lipopolysaccharide- Induced RAW 264.7 Inflamed Cells. In: 2021 IEEE International Conference on Health, Instrumentation & Measurement, and Natural Sciences (InHeNce), 14-16 July 2021, Medan.

Int Proceeding 2021-7 (Ervina IEEE-Wahyu FKUKM).pdf

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During inflammation, the immune system releases proinflammatory mediators. Therefore, suppression of inflammatory mediators has been one of the most valuable strategies for treating inflammatory diseases. Research has shown that medicinal plants have anti-inflammatory properties. This study aimed to investigate the cytotoxicity and protective effect of Aloe vera gel extract (AVGE) on inflamed LPS-stimulated macrophage cells (RAW 264.7 ATCC TIB 71). Based on the cytotoxicity test, Aloe vera gel extract (AVGE) concentrations of 12.5 μg/mL and 75.0 μg/mL were chosen in this research as more than 90% cell viability was seen. Results showed that the level of critical inflammatory mediators observed in this study was significantly reduced by Aloe vera gel extract (AVGE) 75.0 μg/mL concentration and percentage inhibition over positive control, that is, PGE2 (627.42 ± 27.77 pg/mL and 29.79 ± 3.11 pg/mL), TN α (265.7 ± 36.57 pg/mL and 54.24 ± 6.30 pg/mL), and IL-1β (191.33 ± 0.66 pg/mL and 56.23 ± 0.15 pg/mL). Microscopically, the cytokine production was reduced significantly post-treated with Aloe vera gel extract 75.0 micro g/mL concentration. These findings confirmed the protective effect of Aloe vera gel extract (AVGE) towards inflamed cells.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Aloe vera, anti-inflammation, inflammatory mediators, LPS, RAW 264.7
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 24 Mar 2022 04:27
Last Modified: 24 Mar 2022 04:27

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