Ratnawati, Hana (2020) The Role of Tumor Microenvironment in the Pathogenesis of Esophageal Cancer. In: 15th Oeso World Conference for Esophageal Diseases, 8-10 November 2020, Beijing.
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Abstract
Esophageal cancer ranks sixth as the deadliest cancers worldwide and the incidence is rapidly increasing over the past few decades. Risk factors play a big role in the pathogenesis of esophageal cancer and gastroesophageal reflux and inflammation are the main risk factors which can lead to Barrett’s esophagus and metaplasia of the esophagus epithel. Chronic inflammation will affect the surrounding immune cells and trigger transdifferentiation and transcommitment of the esophageal epithel and support the pathogenesis of esophageal cancer. The chronic inflammatory process in Barrett’s esophagus will cause ischemia, edema and activate the immune cells in the tumor microenvironment and induces activation of inflammatory signaling pathways through IL-6/STAT3/NFκB and leads to activation of gene transcription and COX-2 enzym activity that promote cell proliferation and survival. This pathway hijacked by the cancer cell to promote growth, survival, angiogenesis and metastasis. Chronic inflammation is clearly involved in the formation of the tumor microenvironment and development of cancer. A researcher said that human tumors as `wounds that do not heal’.
| Item Type: | Conference or Workshop Item (Paper) |
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| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 22 Mar 2022 03:16 |
| Last Modified: | 22 Mar 2022 03:16 |
| URI: | http://repository.maranatha.edu/id/eprint/30162 |
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