Prahastuti, Sijani and Hidayat, Meilinah and Hasiana, Stella Tinia and Widowati, Wahyu and Widodo, Wahyu Setia and Handayani, Rr. Anisa Siwianti and Rizal, Rizal and Kusuma, Hanna Sari W. (2020) The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants. Pharmaciana, 10 (1). pp. 77-88. ISSN 2477 0256
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Abstract
Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities. Therefore, it is claimed as a source of various plant-based medicines. This research was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic testing, and comparative analysis between the antioxidant activities of EEGU and epicatechin. The qualitative phytochemical screening assay of EEGU detected the availability of phenols, flavonoids, alkaloids, tannins, and terpenoids, but not saponins and triterpenoids. Meanwhile, the total phenolic content was 32.24 μg GAE/mg extract, and the total flavonoid content was 6.48 μg QE/mg extract. The role of antioxidants examined by FRAP, DPPH, H2O2, and ABTS assays. These assays are proved that the IC50 values of EEGU are higher than epicatechin. For DPPH scavenging, H2O2 scavenging, and ABTS reduction activities, EEGU resulted IC50 45.70 μg/mL, 162.93 μg/mL, and 35.96 μg/mL, while epicatechin only yielded IC50 0.56 μg/mL, 57.91 μg/mL, and 16.74 μg/mL respectively. Otherwise, the highest reduction in FRAP activities were shown at 50 μg/mL concentration of epicatechin and EEGU were 236.33 and 202.71 μM Fe (II)/μg respectively. Based on these results, EEGU is concluded as an active natural product because it exhibited antioxidant activities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antioxidant, Guazuma ulmifolia, phytochemical, total flavonoid, total phenolic |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 15 Sep 2021 21:49 |
| Last Modified: | 14 Nov 2022 09:29 |
| URI: | http://repository.maranatha.edu/id/eprint/27833 |
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