An Old Therapy, Convalescent Plasma, for Coronavirus Disease-19: Do We Have All the Answer?

Faried, Ahmad and Widowati, Wahyu and Anwar, Ruswana and Hidajat, Nucki Nursjamsi and Harsono, Ali Budi and Hermanto, Yulius and Azizah, Alya Mardhotillah and Aviani, Jennifer Klem (2020) An Old Therapy, Convalescent Plasma, for Coronavirus Disease-19: Do We Have All the Answer? Open Access Macedonian Journal of Medical Sciences.. ISSN 1857-9655

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BACKGROUND: Coronavirus (CoV) disease (COVID-19) has become a global health pandemic by early 2020; it has pushed the health-care system to its limit. From the initial estimates, 15% of COVID-19 patients caused by severe acute respiratory CoV 2 syndrome present with severe symptoms and requires hospitalization or even intensive care. There is no specific treatment against COVID-19, particularly for those with severe symptoms. Desperation caused by COVID-19 has driven clinicians to try an alternative therapies with little or even no-evidence previously. Convalescent plasma therapy (CPT) has emerged as a promising COVID-19 therapy. AIM: We aimed to review current state of convalescent plasma therapy. METHODS: We summarize the historical CPT, COVID-19 pathology and evaluate potential of CPT for COVID-19; raising the question regarding routinely administrating CPT to the COVID-19 patients, whether it is safe and effective. RESULTS: From cases in Indonesia and other countries, there is bunch of examples that healthcare workers being negatively stigmatized in case of COVID-19. They lost their rights to have a normal life in this pandemic era. A reasonable basis is found in many literatures to advocate the CPT. Convalescent plasma from COVID-19 patients who had been recovered with high neutralizing antibody titers was reported to be effective on transfusion to other COVID-19 patients. CONCLUSION: CPT is one good option to treat COVID-19 patients, but it not without risk; many potential candidate treatment that promising in theory but somehow fall apart when translated into clinical study; only time will tell, including our ongoing CPT clinical study.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 14 Sep 2021 22:19
Last Modified: 14 Nov 2022 04:13

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