Liana, Liana and Rizal, Rizal and Widowati, Wahyu and Fioni, Fioni and Akbar, Khainir and Fachrial, Edy and I Nyoman , E. Lister (2019) Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O Rutinoside. Jurnal Kedokteran Brawijaya, 30 (4). pp. 247-252. ISSN 2338-0772
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Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-ORutinoside 2.pdf Download (504Kb) | Preview |
Abstract
Aging is a natural process in human life and is triggered by the presence of free radicals (ROS). The use of antioxidants from natural ingredients is one of the breakthroughs to overcome aging and counteract the harmful effects caused by the free radicals. This study aimed to determine and compare the antioxidant activity of H O scavenging and hyaluronidase inhibition of red dragon fruit peel extract (DFPE) and kaempferol-3-o-rutinoside (KOR) compounds. ragon fruit peel extract DFPE is obtained through extraction by maceration method using 70% ethanol solvent. The design of this study included antioxidant and anti-aging activity assay of EKBN and KORat the series concentration of 15.63; 31.25; 62.50; 125; 250; 500 μg/mL through H O scavenging, as well as the DFPE and KOR hyaluronidase inhibition assay at the series concentration of 5.21; 10.42; 20.83; 41.7; 83.33; 166.67 μg/mL. EKBN shows that the average activity ofH O scavenging is lower than KOR. In addition, the IC values of KOR for H O scavenging is lower (351.46±2.30ug/mL) than DFPE (409.64±23.17ug/mL). While, KOR also has higher values of inhibitory activity than of the DFPE. However, the IC value of KORfor hyaluronidase inhibition activity was 84.07±10.46μg/mL, equivalent to the IC value of DFPE (85.32±10.24μg/mL). The presence of antioxidant and anti-aging activity in the EKBNis probably caused by betalain and the KORcompound itself contained in red dragon fruit. The results of the paired-samples T-test on antioxidant activity and anti-aging of DFPE and KOR showed non-significant difference. Thus, DFPE has an equivalent antioxidant and anti-aging through H O scavenging and hyaluronidase activity as possessed by the KORcompound.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aging, anti-hyaluronidase, dragon fruit peel extract, kaempferol, H2O2scavenging |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > 10 School of Medicine |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 28 Oct 2019 08:35 |
| Last Modified: | 28 Oct 2019 08:35 |
| URI: | http://repository.maranatha.edu/id/eprint/27079 |
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