Chemical Constituents of Piper Aduncum and Their Inhibitory Effects on Soluble Epoxide Hydrolase and Tyrosinase

Luyen, Bui Thi Thuy and Thao, Nguyen Phuong and Widowati, Wahyu and Fauziah, Nurul and Maesaroh, Maesaroh and Herlina, Tati and Kim, Young Ho (2016) Chemical Constituents of Piper Aduncum and Their Inhibitory Effects on Soluble Epoxide Hydrolase and Tyrosinase. Medical Chemistry Research.

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Official URL: http://link.springer.com/article/10.1007/s00044-01...

Abstract

A new compound, 2(S)-isobutanol 2-O-β-D-arabinopyranosyl( 1→6)-O-β-D-glucopyranoside (1), along with ten known compounds (2–11) were isolated from Piper aduncum L. leaves. The effects of these compounds on soluble epoxide hydrolase and tyrosinase inhibition were evaluated. Among them, compounds 3, 8, and 9 exhibited significant tyrosinase inhibitory activity with IC50 values of 39.3 ± 1.8, 41.3 ± 2.2, and 37.5 ± 2.7 μM, respectively. However, the effects of isolated compounds on soluble epoxide hydrolase inhibition were weak or absent, and compounds 4 and 11 showed the highest inhibitory activity with values of 61.2 ± 4.3 and 60.6 ± 3.7% at a concentration of 100 μM.

Item Type: Article
Uncontrolled Keywords: Piper aduncum, Alkyl glycoside, Soluble epoxide hydrolase, Tyrosinase inhibition
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 25 Nov 2016 09:26
Last Modified: 25 Nov 2016 09:28
URI: http://repository.maranatha.edu/id/eprint/21265

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