Anti-inflammatory Flavonoid C-Glycosides from Piper aduncum Leaves

Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Widowati, Wahyu and Fauziah, Nurul and Maesaroh, Maesaroh and Herlina, Tati and Manzoor, Zahid and Ali, Irshad and Koh, Young Sang and Kim, Young Ho (2016) Anti-inflammatory Flavonoid C-Glycosides from Piper aduncum Leaves. Planta Medica, 82 (17). pp. 1475-1481. ISSN 0032-0943

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Abstract

Four new compounds, acacetin 8-C-[β-D-apiofuranosyl-( 1→2)-β-D-glucopyranoside] (1), 7-methoxyacacetin 8-C-[β-D-apiofuranosyl-(1→3)-β- D-glucopyranoside] (2), 7-methoxyacacetin 8-C- [β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside] (3), and 4′′′-O-acetylacacetin 8-C-[α-Lrhamnopyranosyl-( 1→2)-β-D-glucopyranoside] (4), along with ten known compounds (5–14), were isolated from Piper aduncum leaves. The effects of these compounds on lipopolysaccharideinduced expression of the proinflammatory cytokines IL-12 p40, IL-6, and TNF-α in bone marrowderived dendritic cells were evaluated. Compounds 2, 3, 6, 8, 9, and 11–13 inhibited the production of both IL-12 p40 and IL-6, with IC50 values ranging from 0.35 ± 0.01 to 1.40 ± 0.04 μMand 1.22 ± 0.02 to 3.79 ± 0.10 μM, respectively. Compounds 5 and 10 only showed strong inhibition effects on the production of IL-12 p40, with IC50 values of 2.76 ± 0.08 and 0.39 ± 0.05 μM, respectively. However, all compounds showed weak activity or no activity on TNF-α production at the tested concentrations.

Item Type: Article
Uncontrolled Keywords: piper aduncum, piperaceae, flavonoid C-glycoside, LI-12p40, IL-6, TNF-a, LPS
Subjects: R Medicine > R Medicine (General)
Depositing User: Perpustakaan Maranatha
Date Deposited: 03 Aug 2016 08:42
Last Modified: 16 Oct 2017 09:08
URI: http://repository.maranatha.edu/id/eprint/20719

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