Darsono, Lusiana and Hidayat, Meilinah and Maesaroh, Maesaroh and Fauziah, Nurul and Widowati, Wahyu (2015) Ex Vivo Study of Garcinia Mangostana L. (Mangosteen) Peel Extract and Xanthones as Anti-Adipogenesis in HEPG2 Cell Model. International Journal of Medical Research & Health Sciences, 4 (3). pp. 566-571. ISSN 2139-5886
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11. Ex Vivo Study of Garcinia Mangostana L (Mangosteen) Peel Extract.pdf - Published Version Download (579Kb) | Preview |
Abstract
Background: Anti-adipogenesis is one of proposed mechanism for anti-obesity. Adipogenesis regulation of obesity is important, so identification of anti-adipogenic activity is a potential strategy to find anti-obesity agent. Aim: The aim of this study is to evaluate the anti-adipogenesis potential of Garcinia mangostana L. peel extract (GMPE) compared to xanthones in HepG2 cells line as model. Material and Methods: GMPE was performed based on maceration method using distilated ethanol 70% as the solvent. The level of triglyceride and cholesterol and the inhibitory activity of triglyceride (TG) and cholesterol (CHOL) in HepG2 cells were assayed and determined as the anti-adipogenesis parameter. Results: The most active subtance to lower the triglyceride level was showed by GMPE in every concentration followed by the garcinone-C, γ-mangostin, garcinone-D and α- mangostin respectivelly. The highest activity to decrease the cholesterol level was showed by GMPE and followed by γ-mangostin, α-mangostin, garcinone-c, garcinone-d respectively. Conclusion: GMPE posses the anti-adipogenesis potential in inhibiting TG and CHOL synthesis was better than any other xanthone (α- mangostin, γ-mangostin, garcinone-C and garcinone-D).
| Item Type: | Article |
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| Uncontrolled Keywords: | Obesity, Adipogenesis, Garcinia mangostana L., HepG2, Triglyceride, Cholesterol. |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Perpustakaan Maranatha |
| Date Deposited: | 24 Aug 2015 02:32 |
| Last Modified: | 19 Sep 2016 07:14 |
| URI: | http://repository.maranatha.edu/id/eprint/14524 |
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